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Filaments of keratin — stable protein polymers best known for their function in hair and nails — provide a memory of cell polarity at a crucial stage in early mouse development.
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- Mateusz Trylinski0 &
- Buzz Baum1
- Mateusz Trylinski
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Mateusz Trylinski is in the MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
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- Buzz Baum
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Buzz Baum is in the MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
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The processes by which a single cell — the fertilized egg — gives rise to all the different cell types that make up an adult organism remain some of life’s great mysteries. We know that it takes time for cells in an embryo to settle on a fate, because a single embryo that splits during early development can give rise to twins, triplets and more. But how are cell-fate decisions made, and how do cells coordinate their choices with their peers? Researchers have suggested numerous mechanisms that influence the paths taken by cells in early mammalian embryos. Writing in Nature, Lim et al.1 describe a surprising role for a protein polymer, keratin, in the first of these decision-making processes.
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Nature 585, 352-353 (2020)
doi: https://doi.org/10.1038/d41586-020-02443-w
References
Lim, H. Y. G. et al. Nature 585, 404–409 (2020).
Johnson, M. H. & Ziomek, C. A. Cell 24, 71–80 (1981).
Zenker, J. et al. Cell 173, 776–791 (2018).
Jackson, B. W. et al. Differentiation 17, 161–179 (1980).
Serres, M. P. et al. Dev. Cell 52, 210–222 (2020).
Duarte, S. et al. Nature Commun. 10, 4200 (2019).
Nishioka, N. et al. Dev. Cell 16, 398–410 (2009).
Yamada, S., Wirtz, D. & Coulombe, P. A. J. Struct. Biol. 143, 45–55 (2003).
Knoblich, J. A. Nature Rev. Mol. Cell Biol. 11, 849–860 (2010).
Skamagki, M., Wicher, K. B., Jedrusik, A., Ganguly, S. & Zernicka-Goetz, M. Cell Rep. 3, 442–457 (2013).
Maître, J.-L. et al. Nature 536, 344–348 (2016).
Otzen, D. & Riek, R. Cold Spring Harb. Perspect. Biol. 11, a033860 (2019).
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